Ipswich striker Connor Wickham is sidelined with a thigh problem and Gareth McAuley is out until the new year after Achilles surgery.
Luke Hyam is still out with a hamstring injury but Mark Kennedy could return from his hamstring problem.
Preston's first half of the season was their worst for 55 years. They are bottom of the table, have conceded a whopping 39 Championship goals - more than any other team - and have won only one of their last 11 matches.
Yet there have been some signs of improvement. Under-pressure boss Darren Ferguson's recent loan signings seem to have made an impact, and after back-to-back draws North End will be hoping to pile more misery onto Ipswich, who have suffered five consecutive defeats.
Title-chasing Cardiff's late equaliser last weekend denied Preston a second clean sheet in a row. That seems like progress for Ferguson's side, who had previously not managed a shut-out since August.
And Ferguson is not the only manager feeling the heat at present. Town boss Roy Keane is presiding over the worst run of his managerial career and Ipswich's worst for nearly 16 years. A victory would be a much-needed boost for the Suffolk club - and only their second ever win at Deepdale.
• Ipswich's only victory at Deepdale was a 1-0 win in the second tier in January 1966.
Have your say on this match
• Preston have dropped only two points in their last five home games against Town.
• Preston have taken only three points from the last available 21.
• They have the worst disciplinary record in the Championship, having picked up 41 yellow and three red cards.
• Defender Wayne Brown is set to face his former club.
• Goalkeeper Andy Lonergan is in line for his 200th league appearance for North End, and forward John Parkin his 100th.
• Ipswich have scored only five first-half goals this season, and led at the break in only three of their matches.
• They have won all seven games in which they have scored more than one goal.
• Town have six more points than they had at the same stage last term.
Source: BBC Sport
Source: BBC Sport